VDR is a gene that codes for a protein that acts as a receptor vitamin D that regulates bone development and calcium absorption. A variant of the gene (rs2228570 FokI polymorphism) is associated with a lower bone mineral density in prepubescent girls of white background.

The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is regulated through the reciprocal pattern and temporal on-and-off occupancy of VDRE between the two components. It is also affected by chromosomal positioning and binding preferences for certain hormones. Studies of microarrays in human cells https://www.gescheftmarketing.de/2021/09/01/microsoft-teams-vs-zoom-which-one-is-better/ show that more than 100 genes are enriched with a VDRE. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.

A virtual dataroom (VDR) could be an archive of data and documents that are relevant to business, legal transactions or other procedures. Access to the data, downloading, and printing are all restricted. It is accessed via a central computer and an extranet which is a restricted access Internet connection that allows users to login at specified times.

VDRs are used most often by investment banks and companies involved in mergers or acquisitions. They require a secure platform for sharing information with potential buyers or investors in a way that is transparent, and due diligence can require massive quantities of data. Life science companies also use VDRs to store everything from clinical trials results to HIPAA documentation.